Twist overexpression promotes chromosomal instability in the breast cancer cell line MCF-7
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چکیده
منابع مشابه
The Activity of Sirtuin 1 in MCF-7 Breast Cancer Cell Line: The Effects of Visfatin
Background & Objectives: Breast cancer is the most common cancer and the second leading cause of cancer deaths among women. Obesity, hormones, and growth factors are the risk factors for this kind of cancer. One of the changes observed in patients suffering from breast cancer is the elevated Visfatin or nicotinamide phosphoribosyl transferase (NAMPT) in their tumor tissues and blood. The increa...
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متن کاملCorrelates with Chromosomal Instability in Breast Cancer Angiogenesis and In vivo Twist Overexpression Induces
Aggressive cancer phenotypes are a manifestation of many different genetic alterations that promote rapid proliferation and metastasis. In this study, we show that stable overexpression of Twist in a breast cancer cell line, MCF-7, altered its morphology to a fibroblastic-like phenotype, which exhibited protein markers representative of a mesenchymal transformation. In addition, it was observed...
متن کاملTwist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer.
Aggressive cancer phenotypes are a manifestation of many different genetic alterations that promote rapid proliferation and metastasis. In this study, we show that stable overexpression of Twist in a breast cancer cell line, MCF-7, altered its morphology to a fibroblastic-like phenotype, which exhibited protein markers representative of a mesenchymal transformation. In addition, it was observed...
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ژورنال
عنوان ژورنال: Cancer Genetics and Cytogenetics
سال: 2006
ISSN: 0165-4608
DOI: 10.1016/j.cancergencyto.2006.01.014